Thr77
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr77  -  Chk2 (mouse)

Site Information
SSLETVStQELCSIP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447491

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 3 ) , MEF (fibroblast) ( 3 ) , MEF (fibroblast) [homozygous knockout] ( 1 ) , skin ( 2 )

Upstream Regulation
Regulatory protein:
ATM (mouse) ( 1 ) , NCK1 (mouse) ( 3 )
Treatments:
caffeine ( 2 ) , UV ( 2 , 3 )

References 

1

Davoli T, Denchi EL, de Lange T (2010) Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141, 81-93
20371347   Curated Info

2

Lu YP, et al. (2008) Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. Cancer Res 68, 2523-9
18381462   Curated Info

3

Kremer BE, Adang LA, Macara IG (2007) Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell 130, 837-50
17803907   Curated Info