Tyr18
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Home > Phosphorylation Site Page: > Tyr18  -  Tau iso8 (human)

Site Information
MEDHAGtyGLGDRKD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454024

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 5 , 6 , 7 ) , western blotting ( 1 , 7 )
Disease tissue studied:
Alzheimer's disease ( 4 , 7 ) , neuroblastoma ( 1 , 7 )
Relevant cell line - cell type - tissue:
brain ( 4 , 5 , 7 ) , COS (fibroblast) ( 7 ) , E.coli (bacterial) ( 2 ) , SH-SY5Y (neural crest) ( 1 , 7 )

Upstream Regulation
Kinases, in vitro:
Fyn (human) ( 5 , 6 , 7 ) , Src (human) ( 5 )

Downstream Regulation
Effects of modification on Tau iso8:
molecular association, regulation ( 2 ) , protein stabilization ( 2 )

References 

1

Li J, Chen W, Yi Y, Tong Q (2018) miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease. J Cell Biochem
30556160   Curated Info

2

Stern JL, et al. (2017) Phosphoregulation of Tau modulates inhibition of kinesin-1 motility. Mol Biol Cell 28, 1079-1087
28251926   Curated Info

3

Lebouvier T, et al. (2009) The microtubule-associated protein tau is also phosphorylated on tyrosine. J Alzheimers Dis 18, 1-9
19542604   Curated Info

4

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

5

Bhaskar K, Yen SH, Lee G (2005) Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem 280, 35119-25
16115884   Curated Info

6

Horowitz PM, et al. (2004) Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci 24, 7895-902
15356202   Curated Info

7

Lee G, et al. (2004) Phosphorylation of tau by fyn: implications for Alzheimer's disease. J Neurosci 24, 2304-12
14999081   Curated Info