Ser621
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Home > Phosphorylation Site Page: > Ser621  -  ENaC-alpha (rat)

Site Information
RFRSRYWsPGRGARG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454020

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 ) , SGK1 (human) ( 1 , 2 )
Treatments:
okadaic_acid ( 1 )

Downstream Regulation
Effects of modification on ENaC-alpha:
activity, induced ( 2 ) , intracellular localization ( 1 )

References 

1

Diakov A, et al. (2010) Protein kinase B alpha (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms. Cell Physiol Biochem 26, 913-24
21220922   Curated Info

2

Diakov A, Korbmacher C (2004) A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit. J Biol Chem 279, 38134-42
15234985   Curated Info