Ser624

Site Information
NRsAsEPsLHRAAHT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 18014563

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 )
Disease tissue studied:	cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:	293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 3 ) , 293 (epithelial) ( 1 ) , HeLa S3 (cervical) ( 4 ) , liver ( 2 )

Downstream Regulation
Effects of modification on RAF1:	molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Inhibit interaction with:	14-3-3 beta (human) ( 1 ) , BRAF (human) ( 1 )

References
1	Yu A, Nguyen DH, Nguyen TJ, Wang Z (2023) A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization. J Biol Chem 299, 105188 37625591 Curated Info
2	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
3	Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53 20363803 Curated Info
4	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info