Ser180

Site Information
GGAkRVTsIADrLNV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 18014261

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 3 , 4 , 5 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , breast cancer ( 1 ) , cervical cancer ( 5 ) , cervical adenocarcinoma ( 5 ) , liver cancer ( 1 ) , hepatocellular carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:	'muscle, skeletal' ( 4 ) , A549 (pulmonary) ( 1 ) , BxPC-3 (pancreatic) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa S3 (cervical) ( 3 , 5 ) , Hep 3B2.1-7 (hepatic) ( 1 ) , Huh7 (hepatic) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , U87MG (glial) ( 1 )

Downstream Regulation
Effects of modification on PRPS1:	activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:	cell growth, inhibited ( 1 )

References
1	Qian X, et al. (2018) Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress. Cancer Discov 8, 94-107 29074724 Curated Info
2	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
3	Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457 20860994 Curated Info
4	Zhao X, et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol Cell Proteomics 10, M110.000299 20833797 Curated Info
5	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info