Ser688
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Home > Phosphorylation Site Page: > Ser688  -  palladin (human)

Site Information
APRsAPPsPPFPPPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18013438

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 5 , 7 ) , mutation of modification site ( 6 ) , phospho-antibody ( 6 ) , western blotting ( 6 )
Disease tissue studied:
breast cancer ( 1 , 6 ) , cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 6 )
Kinases, in vitro:
ERK1 (human) ( 6 )
Treatments:
EGF ( 6 )

Downstream Regulation
Effects of modification on palladin:
molecular association, regulation ( 6 )
Effects of modification on biological processes:
cell motility, inhibited ( 6 )
Inhibit interaction with:
Abl (human) ( 6 )

References 

1

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Asano E, et al. (2011) Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration. PLoS One 6, e29338
22216253   Curated Info

7

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info