Ser243
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Home > Phosphorylation Site Page: > Ser243  -  KCTD12 (human)

Site Information
ITVCGKTsLAkEVFG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18011104

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
cervical cancer ( 2 ) , cervical adenocarcinoma ( 2 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )

Downstream Regulation
Effects of modification on KCTD12:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
CDK1 (human) ( 1 )

References 

1

Zhong Y, et al. (2017) KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. Oncogene 36, 6177-6189
28869606   Curated Info

2

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info