Ser591
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.9
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser591  -  SHP-1 (mouse)

Site Information
DKEKNKGsLKRK___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454019

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 8 ) , mass spectrometry ( 4 ) , mutation of modification site ( 7 , 8 ) , phospho-antibody ( 1 , 2 , 6 , 8 ) , western blotting ( 1 , 2 , 6 , 8 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 7 ) , HEK293T (epithelial) ( 8 ) , Jurkat (T lymphocyte) ( 8 ) , liver ( 4 ) , liver [leptin (mouse), homozygous knockout] ( 4 ) , lymphocyte ( 2 ) , macrophage-bone marrow ( 1 ) , mIMCD-3 (epithelial) ( 6 ) , T lymphocyte-blood ( 8 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Regulatory protein:
Fyn (mouse) ( 1 ) , PKCA (mouse) ( 1 )
Putative in vivo kinases:
CDK2 (human) ( 7 ) , PKCT (human) ( 8 )
Kinases, in vitro:
CDK2 (human) ( 7 )
Treatments:
antibody ( 8 ) , bisindolylmaleimide ( 8 ) , GF109203X ( 1 ) , LY294002 ( 1 ) , PD98059 ( 1 )

Downstream Regulation
Effects of modification on SHP-1:
enzymatic activity, inhibited ( 1 , 6 , 8 ) , intracellular localization ( 6 , 8 ) , protein processing ( 7 )

Disease / Diagnostics Relevance
Relevant diseases:
rheumatoid arthritis ( 1 ) , SLE ( 1 )

References 

1

Mkaddem SB, et al. (2017) Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation. Nat Commun 8, 246
28811476   Curated Info

2

Moogk D, et al. (2016) Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol 197, 644-54
27271569   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

5

Ma P, et al. (2012) A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood 119, 1935-45
22210881   Curated Info

6

Zhou X, Gallazzini M, Burg MB, Ferraris JD (2010) Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A 107, 7072-7
20351292   Curated Info

7

Simoneau M, et al. (2008) Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. J Biol Chem 283, 25544-56
18617527   Curated Info

8

Liu Y, Kruhlak MJ, Hao JJ, Shaw S (2007) Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity. J Leukoc Biol 82, 742-51
17575265   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.