Ser697
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Home > Phosphorylation Site Page: > Ser697  -  IKKB (mouse)

Site Information
QPsSACDsLPEsDKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17934903

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 ) , HEK293T (epithelial) ( 3 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Putative in vivo kinases:
IKKB (mouse) ( 3 )
Treatments:
insulin ( 2 ) , wedelolactone ( 3 )

Downstream Regulation
Effects of modification on IKKB:
molecular association, regulation ( 3 ) , phosphorylation ( 3 )
Induce interaction with:
PPP2R3C (human) ( 3 )

References 

1

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Chiang CW, Liu WK, Chiang CW, Chou CK (2010) Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5. Biochem J 433, 187-96
20925653   Curated Info