Ser21
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Home > Phosphorylation Site Page: > Ser21  -  PPAR-alpha (human)

Site Information
LEAGDLEsPLSEEFL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1789803

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CHO (fibroblast) ( 1 ) , hepatocyte-liver ( 3 ) , HepG2 (hepatic) ( 2 , 3 )

Upstream Regulation
Regulatory protein:
HRas (human) ( 1 ) , KRas (human) ( 1 ) , MEK1 (human) ( 1 )
Putative upstream phosphatases:
PPP1CA (human) ( 3 ) , PPP2CA (human) ( 3 )
Treatments:
HDL ( 1 ) , nafenopin ( 3 ) , okadaic_acid ( 3 ) , PD98059 ( 1 ) , pirinixic acid ( 1 , 3 ) , prasterone ( 3 )

Downstream Regulation
Effects of modification on PPAR-alpha:
activity, induced ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, inhibited ( 2 , 3 )

References 

1

Wood P, et al. (2011) Ras/Mitogen-activated Protein Kinase (MAPK) Signaling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI. J Biol Chem 286, 23077-92
21525007   Curated Info

2

Oh KJ, et al. (2011) Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism. Am J Physiol Endocrinol Metab 300, E624-32
21224484   Curated Info

3

Tamasi V, et al. (2008) Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Mol Pharmacol 73, 968-76
18079279   Curated Info

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