Ser618
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Home > Phosphorylation Site Page: > Ser618  -  Abl (human)

Site Information
APtPPKRsssFREMD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1779804

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , [32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PAK2 (human) ( 3 )
Kinases, in vitro:
PAK2 (human) ( 3 )

Downstream Regulation
Effects of modification on Abl:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 3 ) , phosphorylation ( 3 )
Inhibit interaction with:
Abi-2 (human) ( 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Jung JH, Pendergast AM, Zipfel PA, Traugh JA (2008) Phosphorylation of c-Abl by Protein Kinase Pak2 Regulates Differential Binding of ABI2 and CRK. Biochemistry 47, 1094-1104
18161990   Curated Info