Ser179
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Home > Phosphorylation Site Page: > Ser179  -  prolactin (human)

Site Information
NEIYPVWsGLPSLQM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17790903

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ) , phospho-antibody ( 4 ) , western blotting ( 8 )
Disease tissue studied:
breast cancer ( 3 , 8 ) , prostate cancer ( 2 )
Relevant cell line - cell type - tissue:
aorta ( 6 ) , CHO-K1 (fibroblast) ( 8 ) , corneal ( 6 ) , E.coli (bacterial) ( 5 , 7 ) , embryo ( 6 ) , HMVEC (endothelial) ( 6 ) , HUVEC (endothelial) ( 5 , 6 ) , Leydig ( 4 ) , MCF-7 (breast cell) ( 3 , 8 ) , PC3 (prostate cell) ( 2 ) , T47D (breast cell) ( 8 )

Upstream Regulation
Treatments:
PRL ( 8 )

Downstream Regulation
Effects of modification on prolactin:
phosphorylation ( 5 , 6 )
Effects of modification on biological processes:
apoptosis, induced ( 4 , 5 ) , cell cycle regulation ( 3 , 5 ) , cell growth, inhibited ( 7 , 8 ) , cell motility, inhibited ( 6 ) , signaling pathway regulation ( 5 , 6 , 7 ) , transcription, induced ( 5 ) , transcription, inhibited ( 6 )

References 

1

Morales T, Lorenson M, Walker AM, Ramos E (2014) Both prolactin (PRL) and a molecular mimic of phosphorylated PRL, S179D-PRL, protect the hippocampus of female rats against excitotoxicity. Neuroscience 258, 211-7
24252319   Curated Info

2

DU L, Wu W (2012) A mimic of phosphorylated prolactin induces apoptosis by activating AP-1 and upregulating p21/waf1 in human prostate cancer PC3 cells. Oncol Lett 4, 1064-1068
23162652   Curated Info

3

Xie W, et al. (2010) A mimic of phosphorylated prolactin inhibits human breast cancer cell proliferation via upregulation of p21 waf1. Med Oncol 27, 1340-5
20013077   Curated Info

4

Williams VL, et al. (2007) Common and specific effects of the two major forms of prolactin in the rat testis. Am J Physiol Endocrinol Metab 293, E1795-803
17911340   Curated Info

5

Ueda EK, Lo HL, Bartolini P, Walker AM (2006) S179D prolactin primarily uses the extrinsic pathway and mitogen-activated protein kinase signaling to induce apoptosis in human endothelial cells. Endocrinology 147, 4627-37
16840547   Curated Info

6

Ueda E, et al. (2006) A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone. Endocr Relat Cancer 13, 95-111
16601282   Curated Info

7

Wu W, Ginsburg E, Vonderhaar BK, Walker AM (2005) S179D prolactin increases vitamin D receptor and p21 through up-regulation of short 1b prolactin receptor in human prostate cancer cells. Cancer Res 65, 7509-15
16103106   Curated Info

8

Schroeder MD, Brockman JL, Walker AM, Schuler LA (2003) Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL. Endocrinology 144, 5300-7
12970160   Curated Info