Lys142
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Home > Mono-methylation Site Page: > Lys142  -  DNMT1 (human)

Site Information
PRtPRRsksDGEAkP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17772901

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , modification-specific antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
cervical cancer ( 1 ) , liver cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on DNMT1:
phosphorylation ( 3 ) , protein degradation ( 3 ) , ubiquitination ( 3 )

References 

1

Wu Z, et al. (2015) A chemical proteomics approach for global analysis of lysine monomethylome profiling. Mol Cell Proteomics 14, 329-39
25505155   Curated Info

2

Estève PO, et al. (2014) Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation. J Biol Chem 289, 8277-87
24492612   Curated Info

3

Estève PO, et al. (2011) A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol 18, 42-8
21151116   Curated Info