Ser226
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Home > Phosphorylation Site Page: > Ser226  -  MEK2 (rat)

Site Information
LIDsMANsFVGTRSY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448074

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 3 , 4 , 5 ) , western blotting ( 1 , 3 , 5 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 5 ) , 'neuron, cerebellar granule' ( 1 ) , myocardium ( 3 ) , VSMC-aorta ( 4 )

Upstream Regulation
Treatments:
adrenalectomy ( 3 ) , insulin ( 3 ) , metoprolol ( 3 ) , NSC23766 ( 1 ) , okadaic_acid ( 5 )

References 

1

Stankiewicz TR, et al. (2015) Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades. J Biol Chem 290, 9363-76
25666619   Curated Info

2

Flinder LI, et al. (2011) EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase. J Cell Physiol 226, 2267-78
21660950   Curated Info

3

Samuelsson AM, et al. (2006) Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol 291, H787-96
16565309   Curated Info

4

Pinzar E, et al. (2005) Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells. FEBS Lett 579, 5100-4
16139272   Curated Info

5

Mao L, et al. (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-10
15661743   Curated Info