Ser135
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Home > Phosphorylation Site Page: > Ser135  -  NPM-ALK (human)

Site Information
AMQMELQsPEyKLSK   GenPept
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27275118

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 1 ) , anaplastic large cell lymphoma ( 1 ) , T cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
293GP (epithelial) ( 1 ) , Karpas-299 (T lymphocyte) ( 1 ) , SU-DHL1 (T lymphocyte) ( 1 ) , SUP-M2 (T lymphocyte) ( 1 )

Upstream Regulation
Treatments:
PD98059 ( 1 ) , SB203580 ( 1 ) , SP600125 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on NPM-ALK:
phosphorylation ( 1 )
Effects of modification on biological processes:
carcinogenesis, altered ( 1 ) , cell growth, altered ( 1 )

References 

1

Wang P, et al. (2011) Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential. Carcinogenesis 32, 146-53
21045017   Curated Info

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