Ser408
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Home > Phosphorylation Site Page: > Ser408  -  LATS2 (human)

Site Information
PVPSRTNsFNSHQPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17600400

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 6 ) , mutation of modification site ( 7 ) , phospho-antibody ( 1 , 7 ) , western blotting ( 1 , 7 )
Disease tissue studied:
bone cancer ( 7 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 ) , OSCC ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Chk1 (human) ( 1 )
Putative in vivo kinases:
Chk1 (human) ( 7 )
Kinases, in vitro:
Chk2 (human) ( 7 )
Treatments:
Chk2_inhibitor_II ( 7 ) , SB218078 ( 7 ) , siRNA ( 7 ) , UV ( 7 )

Downstream Regulation
Effects of modification on LATS2:
activity, induced ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 7 ) , cell cycle regulation ( 7 ) , signaling pathway regulation ( 1 )

References 

1

Nozaki M, et al. (2019) LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer. Oncotarget 10, 1014-1030
30800215   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

5

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

6

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

7

Okada N, et al. (2011) A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. J Cell Sci 124, 57-67
21118956   Curated Info