Ser408

Site Information
PVPSRTNsFNSHQPR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 17600400

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 6 ) , mutation of modification site ( 7 ) , phospho-antibody ( 1 , 7 ) , western blotting ( 1 , 7 )
Disease tissue studied:	bone cancer ( 7 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 ) , OSCC ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , HeLa (cervical) ( 3 , 6 ) , HeLa S3 (cervical) ( 7 ) , HSC-3 (squamous) ( 1 ) , HSC-4 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 4 ) , SAS (squamous) ( 1 ) , U2OS (bone cell) ( 7 )

Downstream Regulation
Effects of modification on LATS2:	activity, induced ( 1 )
Effects of modification on biological processes:	apoptosis, inhibited ( 7 ) , cell cycle regulation ( 7 ) , signaling pathway regulation ( 1 )

References
1	Nozaki M, et al. (2019) LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer. Oncotarget 10, 1014-1030 30800215 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
5	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
6	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
7	Okada N, et al. (2011) A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. J Cell Sci 124, 57-67 21118956 Curated Info