Ser21
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Home > Phosphorylation Site Page: > Ser21  -  SSH2 (mouse)

Site Information
TTSsPCAsEADsGEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17544228

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 ) , testis ( 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on SSH2:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
cell motility, inhibited ( 1 ) , cytoskeletal reorganization ( 1 )

References 

1

Tang W, et al. (2011) A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 21, 1038-50
22172670   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

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