Thr360

Site Information
sITLKNktEssLLAk SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1737602

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 5 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 3 )
Disease tissue studied:	colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 , 2 , 5 ) , SW480 (intestinal) ( 3 )

Downstream Regulation
Effects of modification on TTK:	intracellular localization ( 1 )
Effects of modification on biological processes:	cell cycle regulation ( 1 )

References
1	Wang X, et al. (2014) Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression. PLoS One 9, e104723 25265012 Curated Info
2	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
3	Xu Q, et al. (2009) Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell 20, 10-20 18923149 Curated Info
4	Jelluma N, et al. (2008) Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One 3, e2415 18545697 Curated Info
5	Kang J, Chen Y, Zhao Y, Yu H (2007) Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A 104, 20232-7 18083840 Curated Info