Ser363
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Home > Phosphorylation Site Page: > Ser363  -  TTK (human)

Site Information
LKNktEssLLAkLEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1737601

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 6 ) , mass spectrometry (in vitro) ( 1 , 4 ) , mutation of modification site ( 2 , 4 )
Disease tissue studied:
colorectal cancer ( 4 ) , colorectal carcinoma ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
TTK (human) ( 2 )
Kinases, in vitro:
PLK1 (human) ( 1 ) , TTK (human) ( 4 , 5 )
Treatments:
MLN8054 ( 3 )

Downstream Regulation
Effects of modification on TTK:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 , 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

von Schubert C, et al. (2015) Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells. Cell Rep 12, 66-78
26119734   Curated Info

2

Wang X, et al. (2014) Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression. PLoS One 9, e104723
25265012   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

4

Xu Q, et al. (2009) Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell 20, 10-20
18923149   Curated Info

5

Jelluma N, et al. (2008) Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One 3, e2415
18545697   Curated Info

6

Kang J, Chen Y, Zhao Y, Yu H (2007) Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A 104, 20232-7
18083840   Curated Info