Ser657
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Home > Phosphorylation Site Page: > Ser657  -  HIF1A (human)

Site Information
EttsATssPYRDTQS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17331802

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK3 (human) ( 2 )
Kinases, in vitro:
PLK3 (human) ( 2 )

Downstream Regulation
Effects of modification on HIF1A:
protein degradation ( 2 )

References 

1

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

2

Xu D, et al. (2010) Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1{alpha}. J Biol Chem 285, 38944-50
20889502   Curated Info