Ser1029
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Home > Phosphorylation Site Page: > Ser1029  -  KIF17 (mouse)

Site Information
SKAKRKKsKNSFGGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1720900

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , hTERT-RPE1 (epithelial) ( 1 ) , LLC-PK1 (renal) ( 1 ) , mIMCD-3 (epithelial) ( 1 ) , Neuro-2a (neuron) ( 3 ) , neuron-'brain, hippocampus' ( 2 ) , retinal-retina ( 1 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (mouse) ( 1 , 3 )
Kinases, in vitro:
CAMK2A (mouse) ( 3 )

Downstream Regulation
Effects of modification on KIF17:
activity, inhibited ( 2 ) , intracellular localization ( 1 ) , molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:
endocytosis, induced ( 1 )
Inhibit interaction with:
APBA1 (mouse) ( 3 )

References 

1

Lewis TR, et al. (2018) Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol 19, 25
30458707   Curated Info

2

Hanus C, et al. (2014) Synaptic control of secretory trafficking in dendrites. Cell Rep 7, 1771-8
24931613   Curated Info

3

Guillaud L, Wong R, Hirokawa N (2008) Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat Cell Biol 10, 19-29
18066053   Curated Info

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