Ser371
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Home > Phosphorylation Site Page: > Ser371  -  NEDD4L (mouse)

Site Information
sSRLRsCsVTDTVAE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453438

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 ) , HEK293T (epithelial) ( 3 ) , mpkCCD (renal) ( 3 ) , T lymphocyte-spleen ( 1 )

Upstream Regulation
Regulatory protein:
SGK1 (mouse) ( 1 )
Putative in vivo kinases:
SGK1 (human) ( 3 )
Treatments:
aldosterone ( 3 ) , insulin ( 2 ) , OVA ( 1 )

Downstream Regulation
Effects of modification on NEDD4L:
intracellular localization ( 3 ) , molecular association, regulation ( 3 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 )
Induce interaction with:
14-3-3 beta (human) ( 3 )

References 

1

Heikamp EB, et al. (2014) The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nat Immunol 15, 457-64
24705297   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Chandran S, et al. (2011) Neural Precursor Cell-expressed Developmentally Down-regulated Protein 4-2 (Nedd4-2) Regulation by 14-3-3 Protein Binding at Canonical Serum and Glucocorticoid Kinase 1 (SGK1) Phosphorylation Sites. J Biol Chem 286, 37830-40
21900244   Curated Info