Ser1119
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Home > Phosphorylation Site Page: > Ser1119  -  TIE2 (human)

Site Information
TyAGIDCsAEEAA__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453441

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 2 , 4 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , EA.hy 926 (endothelial) ( 2 ) , liver ( 3 ) , SF9 ( 4 )

Upstream Regulation
Regulatory protein:
EPCR (human) ( 2 ) , F10 (human) ( 2 ) , PAR3 (human) ( 2 )

Downstream Regulation
Effects of modification on TIE2:
activity, induced ( 2 ) , enzymatic activity, induced ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Stavenuiter F, Mosnier LO (2014) Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity. Blood 124, 3480-9
25320242   Curated Info

3

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

4

(2005) MS catalog #4226 - Phospho-Tie2 (Ser1119) Antibody
Curated Info