Ser7
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser7  -  FANCG (human)

Site Information
_MSRQTTsVGSSCLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453422

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 1 ) , B cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATR (human) ( 1 )
Treatments:
mitomycin_C ( 1 , 2 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on FANCG:
molecular association, regulation ( 1 )
Induce interaction with:
BRCA2 (human) ( 1 ) , FANCD2 (human) ( 1 ) , XRCC3 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Fanconi's anaemia ( 2 )

References 

1

Wilson JB, et al. (2008) FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene 27, 3641-52
18212739   Curated Info

2

Qiao F, et al. (2004) Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway. J Biol Chem 279, 46035-45
15299017   Curated Info