Thr407
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Home > Phosphorylation Site Page: > Thr407  -  CK1E (human)

Site Information
sRIPAsQtsVPFDHL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453420

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 , 6 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 5 , 6 ) , phosphopeptide mapping ( 5 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , neuroblastoma ( 5 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 6 ) , breast ( 1 , 3 ) , Jurkat (T lymphocyte) ( 4 ) , Neuro-2a (neuron) ( 5 ) , WM239A (melanocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK1E (human) ( 6 )
Putative upstream phosphatases:
PPP2CA (human) ( 6 )
Treatments:
ciclosporin ( 5 ) , DHPG ( 5 ) , ischemia ( 3 )

Downstream Regulation
Effects of modification on CK1E:
enzymatic activity, inhibited ( 5 , 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Possemato A (2010) CST Curation Set: 9294; Year: 2010; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
Curated Info

5

Liu F, Virshup DM, Nairn AC, Greengard P (2002) Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem 277, 45393-9
12223474   Curated Info

6

Gietzen KF, Virshup DM (1999) Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. J Biol Chem 274, 32063-70
10542239   Curated Info

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