Thr337
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Home > Phosphorylation Site Page: > Thr337  -  CK1E (human)

Site Information
PGPPtGAtANRLrsA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453419

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , Neuro-2a (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK1E (human) ( 2 )
Putative upstream phosphatases:
PPP2CA (human) ( 2 )
Treatments:
ciclosporin ( 1 ) , DHPG ( 1 )

Downstream Regulation
Effects of modification on CK1E:
enzymatic activity, inhibited ( 1 , 2 )

References 

1

Liu F, Virshup DM, Nairn AC, Greengard P (2002) Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem 277, 45393-9
12223474   Curated Info

2

Gietzen KF, Virshup DM (1999) Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. J Biol Chem 274, 32063-70
10542239   Curated Info

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