Thr325
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Home > Phosphorylation Site Page: > Thr325  -  CK1E (human)

Site Information
GQLrGsAtRALPPGP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453417

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 , 4 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 , 4 ) , phosphopeptide mapping ( 3 )
Disease tissue studied:
breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK1E (human) ( 4 )
Putative upstream phosphatases:
PPP2CA (human) ( 4 )
Treatments:
ciclosporin ( 3 ) , DHPG ( 3 )

Downstream Regulation
Effects of modification on CK1E:
enzymatic activity, inhibited ( 3 , 4 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Possemato A (2008) CST Curation Set: 3661; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS:pSXXXpS
Curated Info

3

Liu F, Virshup DM, Nairn AC, Greengard P (2002) Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem 277, 45393-9
12223474   Curated Info

4

Gietzen KF, Virshup DM (1999) Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. J Biol Chem 274, 32063-70
10542239   Curated Info