Thr224
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Home > Phosphorylation Site Page: > Thr224  -  Kir6.2 (human)

Site Information
MQVVRKTtSPEGEVV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453090

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , COSm6 (renal) ( 1 ) , myocyte-heart ( 2 ) , pancreatic islet ( 1 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 2 ) , CAMK2D (human) ( 1 )
Kinases, in vitro:
CAMK2A (human) ( 2 ) , CAMK2D (human) ( 1 )
Treatments:
autocamtide_inhibitory_peptide ( 1 ) , isoproterenol ( 1 )

Downstream Regulation
Effects of modification on Kir6.2:
activity, inhibited ( 1 ) , receptor internalization, induced ( 2 )

References 

1

Kline CF, et al. (2013) ╬▓IV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells. Proc Natl Acad Sci U S A 110, 17576-81
24101510   Curated Info

2

Sierra A, et al. (2013) Regulation of Cardiac ATP-sensitive Potassium Channel Surface Expression by Calcium/Calmodulin-dependent Protein Kinase II. J Biol Chem 288, 1568-81
23223335   Curated Info