Ser359

Site Information
KKARVGGsDEEAsGI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 452983

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 )
Disease tissue studied:	bone cancer ( 53 ) , osteosarcoma ( 53 ) , breast cancer ( 5 , 11 , 12 , 24 , 25 ) , breast ductal carcinoma ( 11 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 , 11 ) , cervical cancer ( 54 ) , cervical adenocarcinoma ( 54 ) , leukemia ( 26 , 30 , 68 , 69 ) , acute myelogenous leukemia ( 26 , 30 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 23 ) , acute megakaryoblastic leukemia (M7) ( 23 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 23 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 23 ) , acute myeloblastic leukemia, without maturation (M1) ( 23 ) , chronic myelogenous leukemia ( 68 , 69 ) , hepatocellular carcinoma, surrounding tissue ( 52 ) , lung cancer ( 9 , 17 , 25 , 37 , 43 , 65 ) , non-small cell lung cancer ( 25 , 65 ) , non-small cell lung adenocarcinoma ( 9 , 17 , 37 ) , lymphoma ( 13 ) , B cell lymphoma ( 23 ) , Burkitt's lymphoma ( 13 ) , non-Hodgkin's lymphoma ( 23 ) , follicular lymphoma ( 13 ) , mantle cell lymphoma ( 13 ) , neuroblastoma ( 22 ) , ovarian cancer ( 11 ) , pancreatic ductal adenocarcinoma ( 16 ) , multiple myeloma ( 23 ) , melanoma skin cancer ( 8 )
Relevant cell line - cell type - tissue:	'muscle, skeletal' ( 31 ) , 'pancreatic, ductal'-pancreas ( 16 ) , 'stem, embryonic' ( 59 ) , 293 (epithelial) [ADRB1 (human), no information, overexpresses human beta1-adrenergic (ß1AR- HEK293)] ( 70 ) , 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 46 ) , 293 (epithelial) [AT1 (human), transfection] ( 45 ) , 293 (epithelial) ( 61 ) , 293E (epithelial) ( 36 ) , 786-O (renal) [VHL (human), transfection] ( 6 ) , A498 (renal) ( 51 ) , A549 (pulmonary) ( 18 ) , AML-193 (monocyte) ( 23 ) , BJAB (B lymphocyte) ( 13 ) , breast ( 2 , 11 ) , BT-20 (breast cell) ( 25 ) , BT-474 (breast cell) ( 5 ) , BT-549 (breast cell) ( 25 ) , Calu 6 (pulmonary) ( 25 ) , CL1-0 (pulmonary) ( 43 ) , CL1-1 (pulmonary) ( 43 ) , CL1-2 (pulmonary) ( 43 ) , CL1-5 (pulmonary) ( 43 ) , CMK (megakaryoblast) ( 23 ) , CTS (myeloid) ( 23 ) , DG75 (B lymphocyte) ( 44 ) , DOHH2 ('B lymphocyte, precursor') ( 23 ) , endothelial-aorta ( 27 ) , FL-18 (B lymphocyte) ( 13 ) , FL-318 (B lymphocyte) ( 13 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 28 ) , Flp-In T-Rex-293 (epithelial) ( 28 ) , GM00130 (B lymphocyte) ( 50 ) , H2009 (pulmonary) ( 25 ) , H2077 (pulmonary) ( 25 ) , H2887 (pulmonary) ( 25 ) , H322M (pulmonary) ( 25 ) , HCC1359 (pulmonary) ( 25 ) , HCC1937 (breast cell) ( 25 ) , HCC2279 (pulmonary) ( 25 ) , HCC366 (pulmonary) ( 25 ) , HCC4006 (pulmonary) ( 25 ) , HCC78 (pulmonary) ( 25 ) , HCC827 (pulmonary) ( 25 ) , HCT116 (intestinal) ( 60 , 62 ) , HEK293T (epithelial) ( 7 ) , HEL (erythroid) ( 23 ) , HeLa (cervical) [OGT (rat), transfection] ( 55 ) , HeLa (cervical) ( 1 , 10 , 21 , 32 , 42 , 55 , 56 , 62 , 63 , 67 , 70 , 71 , 72 , 73 , 74 , 75 ) , HeLa S3 (cervical) [PLK1 (human), knockdown, Tet-inducible PLK1 siRNA] ( 40 ) , HeLa S3 (cervical) ( 40 , 54 , 57 , 66 ) , HeLa_Meta (cervical) ( 49 ) , HeLa_Pro (cervical) ( 49 ) , HeLa_Telo (cervical) ( 49 ) , hepatocyte-liver ( 52 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 12 ) , HMLER ('stem, breast cancer') ( 12 ) , HOP62 (pulmonary) ( 25 ) , HUES-7 ('stem, embryonic') ( 58 ) , HUES-9 ('stem, embryonic') ( 41 ) , JEKO-1 (B lymphocyte) ( 13 ) , Jurkat (T lymphocyte) ( 19 , 33 , 34 , 35 , 38 , 39 , 64 ) , K562 (erythroid) ( 21 , 56 , 68 , 69 ) , Kasumi-1 (myeloid) ( 23 ) , KG-1 (myeloid) ( 23 , 30 ) , LCLC-103H (pulmonary) ( 25 ) , leukocyte-blood ( 53 ) , liver ( 15 ) , LOU-NH91 (squamous) ( 25 ) , lung ( 17 ) , MCF-7 (breast cell) ( 4 , 5 , 25 ) , MDA-MB-231 (breast cell) ( 25 ) , MDA-MB-468 (breast cell) ( 25 ) , MV4-11 (macrophage) ( 23 , 26 , 60 ) , NB10 (neural crest) ( 22 ) , NCEB-1 (B lymphocyte) ( 13 ) , NCI-H1299 (pulmonary) ( 65 ) , NCI-H1395 (pulmonary) ( 25 ) , NCI-H1568 (pulmonary) ( 25 ) , NCI-H157 (pulmonary) ( 25 ) , NCI-H1648 (pulmonary) ( 25 ) , NCI-H1666 (pulmonary) ( 25 ) , NCI-H2030 (pulmonary) ( 25 ) , NCI-H2172 (pulmonary) ( 25 ) , NCI-H322 (pulmonary) ( 25 ) , NCI-H460 (pulmonary) ( 25 , 62 ) , NCI-H520 (squamous) ( 25 ) , NCI-H647 (pulmonary) ( 25 ) , NPC (neural crest) ( 22 ) , OCI-ly1 (B lymphocyte) ( 13 ) , OPM-2 (plasma cell) ( 23 ) , ovary ( 11 ) , P31/FUJ (erythroid) ( 23 , 26 ) , PC9 (pulmonary) ( 9 , 25 ) , Raji (B lymphocyte) ( 13 ) , RAMOS (B lymphocyte) ( 13 ) , REC-1 (B lymphocyte) ( 13 ) , RL ('B lymphocyte, precursor') ( 23 ) , RPMI-8266 (plasma cell) ( 23 ) , SH-SY5Y (neural crest) [LRRK2 (human), transfection, over-expression of LRRK2(G2019S)] ( 14 ) , SH-SY5Y (neural crest) ( 14 ) , SKBr3 (breast cell) ( 24 ) , SU-DHL-4 (B lymphocyte) ( 13 ) , SU-DHL-6 (B lymphocyte) ( 23 ) , U-1810 (pulmonary) [EFNB3 (human), knockdown] ( 37 ) , U-1810 (pulmonary) ( 37 ) , U266 (plasma cell) ( 23 ) , U2OS (bone cell) ( 53 ) , UPN-1 (B lymphocyte) ( 13 ) , WM239A (melanocyte) ( 8 )

Upstream Regulation
Treatments:	metastatic potential ( 43 ) , metformin ( 4 ) , MG132_withdrawal ( 49 )

References
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3	Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610 27184836 Curated Info
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5	Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290 27362937 Curated Info
6	Malec V, Coulson JM, Urbé S, Clague MJ (2015) Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. J Proteome Res 14, 5263-72 26506913 Curated Info
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8	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
9	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
10	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
11	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
12	Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90 24782546 Curated Info
13	Rolland D, et al. (2014) Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas. Am J Pathol 184, 1331-42 24667141 Curated Info
14	Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76 24117733 Curated Info
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21	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
22	DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513 24349301 Curated Info
23	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
24	Imami K, et al. (2012) Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics 11, 1741-57 22964224 Curated Info
25	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
26	Alcolea MP, et al. (2012) Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics 11, 453-66 22547687 Curated Info
27	Verano-Braga T, et al. (2012) Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res 11, 3370-81 22497526 Curated Info
28	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
29	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
30	Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56 22115753 Curated Info
31	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
32	Grosstessner-Hain K, et al. (2011) Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics 10, M111.008540 21857030 Curated Info
33	Mulhern D (2011) CST Curation Set: 12431; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Curated Info
34	Guo A (2011) CST Curation Set: 12077; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTDXEAntibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) CK2 Substrate (P-S/T3-100) Rabbit mAb Cat#: 8738 Curated Info
35	Guo A (2011) CST Curation Set: 12078; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTDXEAntibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) CK2 Substrate (P-S/T3-100) Rabbit mAb Cat#: 8738 Curated Info
36	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
37	Ståhl S, et al. (2011) Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. J Proteome Res 10, 2566-78 21413766 Curated Info
38	Guo A (2011) CST Curation Set: 11848; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Curated Info
39	Guo A (2011) CST Curation Set: 11849; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTDXEAntibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) CK2 Substrate (P-S/T3-100) Rabbit mAb Cat#: 8738 Curated Info
40	Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457 20860994 Curated Info
41	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
42	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
43	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info
44	Iliuk AB, et al. (2010) In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Mol Cell Proteomics 9, 2162-72 20562096 Curated Info
45	Xiao K, et al. (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 107, 15299-304 20686112 Curated Info
46	Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53 20363803 Curated Info
47	Zhou J (2010) CST Curation Set: 10002; Year: 2010; Biosample/Treatment: cell line, no cells/untreated &'\|\|' untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
48	Zhou J (2010) CST Curation Set: 10003; Year: 2010; Biosample/Treatment: cell line, no cells/calyculin_A & pervanadate; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
49	Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81 20097925 Curated Info
50	Bennetzen MV, et al. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 9, 1314-23 20164059 Curated Info
51	Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62 20071362 Curated Info
52	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
53	Raijmakers R, et al. (2010) Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem 82, 824-32 20058876 Curated Info
54	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
55	Wang Z, et al. (2010) Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 3, ra2 20068230 Curated Info
56	Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808 19651622 Curated Info
57	Malik R, et al. (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8, 4553-63 19691289 Curated Info
58	Van Hoof D, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 5, 214-26 19664995 Curated Info
59	Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13 19664994 Curated Info
60	Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64 19369195 Curated Info
61	Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501 19413330 Curated Info
62	Nagano K, et al. (2009) Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Proteomics 9, 2861-74 19415658 Curated Info
63	Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8 19276368 Curated Info
64	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info
65	Tsai CF, et al. (2008) Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics. J Proteome Res 7, 4058-69 18707149 Curated Info
66	Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48 18691976 Curated Info
67	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info
68	Stokes M (2008) CST Curation Set: 4391; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
69	Stokes M (2008) CST Curation Set: 4392; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
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71	McNulty DE, Annan RS (2008) Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection. Mol Cell Proteomics 7, 971-80 18212344 Curated Info
72	Cantin GT, et al. (2008) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res 7, 1346-51 18220336 Curated Info
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74	Nousiainen M, et al. (2006) Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A 103, 5391-6 16565220 Curated Info
75	Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5 15302935 Curated Info