Ser92
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Home > Phosphorylation Site Page: > Ser92  -  Snail1 (human)

Site Information
VAELTsLsDEDsGKG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452602

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , [32P] ATP in vitro ( 2 ) , [32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 1 , 4 , 6 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 2 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 ) , CK2B (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 , 5 ) , CK2B (human) ( 2 )
Treatments:
siRNA ( 2 ) , TBB ( 2 )

Downstream Regulation
Effects of modification on Snail1:
activity, inhibited ( 5 ) , molecular association, regulation ( 5 ) , protein degradation ( 2 , 5 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , transcription, altered ( 5 ) , transcription, inhibited ( 2 )
Induce interaction with:
SAP30 (human) ( 5 )

References 

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Deshiere A, et al. (2013) Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction. Oncogene 32, 1373-83
22562247   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

5

MacPherson MR, et al. (2010) Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell 21, 244-53
19923321   Curated Info

6

Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5
15302935   Curated Info