Ser308
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Home > Phosphorylation Site Page: > Ser308  -  CDKL5 (human)

Site Information
RLLDRsPsRSAKRkP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15719610

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
HeLa_Meta (cervical) ( 2 ) , HeLa_Pro (cervical) ( 2 ) , HeLa_Telo (cervical) ( 2 ) , Neuro-2a (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
DYRK1A (human) ( 1 )
Kinases, in vitro:
DYRK1A (human) ( 1 )

Downstream Regulation
Effects of modification on CDKL5:
intracellular localization ( 1 )

References 

1

Oi A, et al. (2017) Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). Biochem Biophys Res Commun 482, 239-245
27840050   Curated Info

2

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info