Ser27
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Home > Phosphorylation Site Page: > Ser27  -  SHIP (human)

Site Information
SRTGkDGsFLVRAsE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15621800

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , NCI-H1299 (pulmonary) ( 1 )

Downstream Regulation
Effects of modification on SHIP:
protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )

References 

1

Ehm PAH, et al. (2019) Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins. Cell Signal 63, 109380
31377397   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info