Ser491
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Home > Phosphorylation Site Page: > Ser491  -  TELO2 (human)

Site Information
GsDsDLDsDDEFVPY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15668106

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 , 4 ) , mass spectrometry ( 1 , 3 ) , mutation of modification site ( 1 , 2 , 4 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 4 ) , U2OS (bone cell) ( 2 )

Upstream Regulation
Regulatory protein:
IHPK2 (human) ( 2 ) , PPIP5K1 (human) ( 2 ) , PPIP5K2 (human) ( 2 )
Putative in vivo kinases:
CK2A1 (human) ( 4 )
Kinases, in vitro:
CK2A1 (human) ( 4 )

Downstream Regulation
Effects of modification on TELO2:
enzymatic activity, induced ( 2 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 , 2 , 4 )
Induce interaction with:
ATM (human) ( 2 ) , DNAPK (human) ( 2 ) , PIH1D1 (human) ( 1 , 4 )

References 

1

Hořejší Z, et al. (2014) Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex. Cell Rep 7, 19-26
24656813   Curated Info

2

Rao F, et al. (2014) Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell 54, 119-32
24657168   Curated Info

3

Fernández-Sáiz V, et al. (2013) SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol 15, 72-81
23263282   Curated Info

4

Horejsí Z, et al. (2010) CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell 39, 839-50
20864032   Curated Info

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