Ser310
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Home > Phosphorylation Site Page: > Ser310  -  PSEN1 (human)

Site Information
PEAQRRVsKNskyNA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452183

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (cow) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Maesako M, et al. (2017) Pathogenic PS1 phosphorylation at Ser367. Elife 6
28132667   Curated Info

2

Fluhrer R, Friedlein A, Haass C, Walter J (2004) Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem 279, 1585-93
14576165   Curated Info

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