Tyr876
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr876  -  GluR2 (human)

Site Information
YKEGYNVyGIEsVKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452173

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 3 ) , glioblastoma ( 3 ) , glioma ( 3 ) , neuroblastoma ( 4 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , 'brain, visual cortex' ( 2 ) , 'neuron, cortical'-brain ( 1 ) , 293 (epithelial) ( 1 ) , glial-brain ( 3 ) , SK-N-BE(2) (neural crest) ( 4 )

Downstream Regulation
Effects of modification on GluR2:
molecular association, regulation ( 2 )
Inhibit interaction with:
GRIP1 (human) ( 2 )

References 

1

Yong AJH, et al. (2020) Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. Proc Natl Acad Sci U S A
32071234   Curated Info

2

Gainey MA, et al. (2015) Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. Proc Natl Acad Sci U S A 112, E3590-9
26109571   Curated Info

3

Johnson H, White FM (2014) Quantitative analysis of signaling networks across differentially embedded tumors highlights interpatient heterogeneity in human glioblastoma. J Proteome Res 13, 4581-93
24927040   Curated Info

4

Guo A (2010) CST Curation Set: 10551; Year: 2010; Biosample/Treatment: cell line, SKNBE(2)/NGF; Disease: neuroblastoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info