Tyr876
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Home > Phosphorylation Site Page: > Tyr876  -  GluR2 (mouse)

Site Information
YkEGYNVyGIEsVKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452173

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 1 , 8 ) , phospho-antibody ( 1 , 8 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 4 ) , 'brain, hippocampus' ( 1 ) , 'neuron, cortical'-brain ( 1 ) , 293 (epithelial) ( 1 ) , brain ( 2 , 5 , 6 , 7 ) , HEK293T (epithelial) [GluR2 (mouse)] ( 8 ) , HEK293T (epithelial) [LYN (human)] ( 8 )

Upstream Regulation
Putative in vivo kinases:
LYN (human) ( 8 )
Treatments:
PP2 ( 1 ) , vanadate ( 1 )

Downstream Regulation
Effects of modification on GluR2:
molecular association, regulation ( 3 , 8 )
Inhibit interaction with:
IQSEC1 (mouse) ( 3 )

References 

1

Yong AJH, et al. (2020) Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. Proc Natl Acad Sci U S A
32071234   Curated Info

2

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

3

Scholz R, et al. (2010) AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron 66, 768-80
20547133   Curated Info

4

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

5

Zhou J (2008) CST Curation Set: 4322; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY
Curated Info

6

Ballif BA, Carey GR, Sunyaev SR, Gygi SP (2008) Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res 7, 311-8
18034455   Curated Info

7

Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Hayashi T, Huganir RL (2004) Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases. J Neurosci 24, 6152-60
15240807   Curated Info