Tyr368

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Home > Phosphorylation Site Page: > Tyr368 - DRP1 (human)

Site Information
CGGARICyIFHETFG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 15569023

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Putative in vivo kinases:	Abl (human) ( 1 )
Kinases, in vitro:	Abl (human) ( 1 )

Downstream Regulation
Effects of modification on DRP1:	activity, induced ( 1 )

References
1	Zhou L, et al. (2017) c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death Dis 8, e3117 29022905 Curated Info

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