Thr283
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Home > Phosphorylation Site Page: > Thr283  -  CCND3 (mouse)

Site Information
QGPSQTStPTDVTAI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452160

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , B lymphocyte ( 1 ) , C2 (myoblast) ( 2 ) , CC42 ( 2 ) , thymocyte ( 1 )

Upstream Regulation
Regulatory protein:
PRB1 (human) ( 2 ) , Rb (human) ( 2 )
Putative in vivo kinases:
GSK3B (mouse) ( 2 )
Kinases, in vitro:
DYRK1A (human) ( 1 ) , GSK3B (mouse) ( 2 )
Treatments:
lithium ( 2 )

Downstream Regulation
Effects of modification on CCND3:
intracellular localization ( 2 ) , protein degradation ( 1 , 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cell differentiation, induced ( 1 , 2 ) , cell growth, inhibited ( 2 ) , transcription, inhibited ( 1 )

References 

1

Thompson BJ, et al. (2015) DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med 212, 953-70
26008897   Curated Info

2

De Santa F, et al. (2007) pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation. Mol Cell Biol 27, 7248-65
17709384   Curated Info