Tyr398
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Home > Phosphorylation Site Page: > Tyr398  -  PVR (human)

Site Information
SANGHVSySAVsREN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450742

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mutation of modification site ( 6 ) , phospho-antibody ( 6 )
Disease tissue studied:
gastric cancer ( 3 , 4 , 5 ) , gastric carcinoma ( 3 , 4 ) , lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 4 ) , ovarian cancer ( 1 , 2 ) , ovarian epithelial carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [PVR (human)] ( 6 ) , MKN-45 (gastric) ( 3 , 4 , 5 ) , NCI-H3255 (pulmonary) ( 4 ) , OVMANA (ovarian) ( 1 , 2 )

Upstream Regulation
Regulatory protein:
PVR (human) ( 6 )
Treatments:
antibody ( 6 ) , DNAM-1 ( 6 ) , poliovirus ( 6 ) , Su11274 ( 4 )

Downstream Regulation
Effects of modification on PVR:
molecular association, regulation ( 6 )

References 

1

Ren H (2011) CST Curation Set: 11303; Year: 2011; Biosample/Treatment: cell line, OVMANA/serum starved; Disease: ovarian epithelial carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Ren H (2010) CST Curation Set: 10744; Year: 2010; Biosample/Treatment: cell line, OVMANA/serum starved; Disease: ovarian epithelial carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Moritz A (2010) CST Curation Set: 9687; Year: 2010; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

5

Moritz A (2008) CST Curation Set: 5772; Year: 2008; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Oda T, Ohka S, Nomoto A (2004) Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Biochem Biophys Res Commun 319, 1253-64
15194502   Curated Info

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