Ser1203
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Home > Phosphorylation Site Page: > Ser1203  -  IBTK (human)

Site Information
LHsVsSksFRDFLLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15483703

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 5 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mass spectrometry (in vitro) ( 5 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lymphoma ( 5 ) , B cell lymphoma ( 5 )
Relevant cell line - cell type - tissue:
B lymphocyte-spleen ( 5 ) , breast ( 1 , 2 ) , DeFew (B lymphocyte) ( 5 ) , DT40 (B lymphocyte) ( 5 ) , HEK293T (epithelial) ( 5 ) , Jurkat (T lymphocyte) ( 3 ) , K562 (erythroid) ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKCB (human) ( 5 )
Kinases, in vitro:
PKCB (human) ( 5 )

Downstream Regulation
Effects of modification on IBTK:
activity, induced ( 5 ) , enzymatic activity, induced ( 5 ) , intracellular localization ( 5 ) , molecular association, regulation ( 5 )
Inhibit interaction with:
Btk (human) ( 5 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

5

Janda E, et al. (2011) Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ. Blood 117, 6520-31
21482705   Curated Info

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