Thr417
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Home > Phosphorylation Site Page: > Thr417  -  ELK1 (human)

Site Information
ISVDGLstPVVLsPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452139

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , immunoassay ( 1 , 4 ) , mass spectrometry ( 5 ) , mutation of modification site ( 4 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 7 ) , phosphoamino acid analysis ( 6 ) , phosphopeptide mapping ( 6 ) , western blotting ( 3 )
Disease tissue studied:
bladder cancer ( 3 ) , brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 ) , breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 ) , esophageal cancer ( 3 ) , esophageal carcinoma ( 3 ) , gastric cancer ( 3 ) , gastric carcinoma ( 3 ) , liver cancer ( 3 ) , hepatocellular carcinoma ( 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 7 ) , 661W ( 1 ) , colon ( 3 ) , COS (fibroblast) ( 6 ) , kidney ( 3 ) , NCI-H1703 (squamous) ( 5 ) , neuron-'brain, hippocampus' ( 4 ) , prostate ( 3 ) , retina ( 1 ) , skin ( 3 ) , stomach ( 3 ) , U87MG (glial) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PRP4 (human) ( 6 )
Kinases, in vitro:
PRP4 (human) ( 6 )
Treatments:
high-fat diet ( 1 ) , miRNA ( 1 ) , palmitate ( 1 ) , phorbol_ester ( 7 ) , serum ( 7 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ADLB ( 4 ) , colorectal carcinoma ( 3 ) , Huntington's disease ( 4 ) , LBD ( 4 )

References 

1

Yu F, Ko ML, Ko GY (2021) Decreased MicroRNA-150 Exacerbates Neuronal Apoptosis in the Diabetic Retina. Biomedicines 9
34572320   Curated Info

2

Demir O, Kurnaz IA (2013) Phospho-Ser383-Elk-1 is localized to the mitotic spindles during cell cycle and interacts with mitotic kinase Aurora-A. Cell Biochem Funct 31, 591-8
23322625   Curated Info

3

Morris JF, et al. (2013) Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Hum Pathol 44, 766-76
23114923   Curated Info

4

Sharma A, et al. (2010) A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS One 5, e9002
20126313   Curated Info

5

Possemato A (2006) CST Curation Set: 1666; Year: 2006; Biosample/Treatment: cell line, NCI-H1703/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

6

Huang Y, Deng T, Winston BW (2000) Characterization of hPRP4 kinase activation: potential role in signaling. Biochem Biophys Res Commun 271, 456-63
10799319   Curated Info

7

Cruzalegui FH, Cano E, Treisman R (1999) ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 18, 7948-57
10637505   Curated Info

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