Ser247
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Home > Phosphorylation Site Page: > Ser247  -  HIF1A (human)

Site Information
KTFLSRHsLDMkFSY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15434302

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , S.cerevisiae ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK1D (human) ( 1 )
Kinases, in vitro:
CK1D (human) ( 1 )
Treatments:
CKI-7 ( 1 ) , hypoxia ( 1 ) , IC261 ( 1 ) , PF-670462 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on HIF1A:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, altered ( 1 ) , cell cycle regulation ( 1 ) , transcription, inhibited ( 1 )
Inhibit interaction with:
ARNT (human) ( 1 )

References 

1

Kalousi A, et al. (2010) Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. J Cell Sci 123, 2976-86
20699359   Curated Info