Ser390
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Home > Phosphorylation Site Page: > Ser390  -  DUSP4 (mouse)

Site Information
SNLPYLHsPITTsPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15412243

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 )
Kinases, in vitro:
ERK1 (human) ( 1 )
Treatments:
phorbol_ester ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on DUSP4:
protein stabilization ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal cancer ( 1 )

References 

1

Cagnol S, Rivard N (2013) Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. Oncogene 32, 564-76
22430215   Curated Info

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