Lys247

Site Information
LkAGKATkVGkDELF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 15388565

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 2 )
Disease tissue studied:	leukemia ( 3 ) , chronic myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 2 ) , HEp-2 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , K562 (erythroid) ( 3 )

Downstream Regulation
Effects of modification on biological processes:	cytoskeletal reorganization ( 2 )

References
1	Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640 29967540 Curated Info
2	Lin S, et al. (2016) Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. J Biol Chem 291, 27323-27333 27879315 Curated Info
3	Moritz A (2010) CST Curation Set: 9063; Year: 2010; Biosample/Treatment: cell line, K-562/Peroxide; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: Ub(K-e-GG) Curated Info