Tyr142
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Home > Phosphorylation Site Page: > Tyr142  -  FBX5 (human)

Site Information
ALETSRLyEDsGYSs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15339200

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
BCR-ABL1 (human) ( 1 )
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 1 )
Treatments:
SU6656 ( 1 )

Downstream Regulation
Effects of modification on FBX5:
protein stabilization ( 1 )

References 

1

Chen JY, Wang MC, Hung WC (2011) Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol 226, 407-13
20717963   Curated Info