Lys191

Site Information
TkVILHLkEDQtEyL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 15291629

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:	colorectal cancer ( 4 , 5 ) , colorectal carcinoma ( 4 , 5 ) , leukemia ( 1 , 3 ) , acute myelogenous leukemia ( 1 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 ) , chronic myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:	HCT116 (intestinal) ( 4 , 5 ) , HEL 92.1.7 (erythroblast) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , K562 (erythroid) ( 3 )

Upstream Regulation
Regulatory protein:	HDAC6 (human) ( 1 )

References
1	Yue L, et al. (2020) HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms. Blood 135, 191-207 31750881 Curated Info
2	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
3	Moritz A (2010) CST Curation Set: 9818; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
4	Moritz A (2010) CST Curation Set: 9796; Year: 2010; Biosample/Treatment: cell line, HCT 116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
5	Moritz A (2010) CST Curation Set: 9797; Year: 2010; Biosample/Treatment: cell line, HCT 116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info