Lys786

Site Information
QEKDPKIkTETSEEG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1505897101

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , MCF-7 (breast cell) ( 1 )

Downstream Regulation
Effects of modification on SRC-3:	activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:	ER-alpha (human) ( 1 )

References
1	Wu RC, Feng Q, Lonard DM, O'Malley BW (2007) SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell 129, 1125-40 17574025 Curated Info