Lys461
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Home > Ubiquitylation Site Page: > Lys461  -  MAVS (human)

Site Information
GPEENEYkSEGTFGI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14991109

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 1 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Treatments:
siRNA ( 2 ) , virus infection ( 2 )

Downstream Regulation
Effects of modification on MAVS:
molecular association, regulation ( 1 ) , protein degradation ( 2 )
Induce interaction with:
MAVS (human) ( 1 )

References 

1

Liu B, et al. (2017) The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol 18, 214-224
27992402   Curated Info

2

Zhong B, et al. (2010) The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J Immunol 184, 6249-55
20483786   Curated Info

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