Lys501
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Ubiquitylation Site Page: > Lys501  -  BACE (human)

Site Information
ADDIsLLk_______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14991108

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 1 , 2 , 3 ) , glioma ( 1 , 2 , 3 ) , neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on BACE:
intracellular localization ( 1 , 2 ) , protein degradation ( 1 , 2 , 3 )

References 

1

Yeates EF, Tesco G (2016) The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. J Biol Chem 291, 15753-66
27302062   Curated Info

2

Kang EL, Biscaro B, Piazza F, Tesco G (2012) BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus. J Biol Chem 287, 42867-80
23109336   Curated Info

3

Kang EL, et al. (2010) Ubiquitin regulates GGA3-mediated degradation of BACE1. J Biol Chem 285, 24108-19
20484053   Curated Info