Tyr254
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Home > Phosphorylation Site Page: > Tyr254  -  RHOU (human)

Site Information
SkSWWKKyCCFV___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14918203

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
MDCKII (epithelial) ( 1 ) , MEF (fibroblast) ( 1 ) , NCI-H1299 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Treatments:
serum ( 1 ) , SU6656 ( 1 )

Downstream Regulation
Effects of modification on RHOU:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 ) , cytoskeletal reorganization ( 1 )
Inhibit interaction with:
PAK1 (human) ( 1 )

References 

1

Alan JK, et al. (2010) Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src. Mol Cell Biol 30, 4324-38
20547754   Curated Info